Many of the experienced Nootropics users have heard of Tenoten. As manufacturers and vendors claims, it is an anti-anxiety supplement with some nootropic activity. Those who want to try it faced the problem of availability – most vendors are not US-based. They ship directly from Russia, and that means high shipping costs and time, and possible problems with customs. So, there is not much info available about it in the English part of the internet, since not many people have tried it.
In this post, I’ll try to shed light on this nootropic for the English-speaking Nootropics user community.
What Tenoten is and how it works
Tenoten is a novel homeopathic anxiolytic with mild nootropic and antidepressant activity. The active ingredient is antibodies to brain-specific protein S100 that is expressed and secreted by astrocytes and microglial cells.
It acts as anxiolytic by interacting with GABA-A receptors and the opening of a chloride ion-selective channels. The drug modulates synaptic plasticity and increases brain resistance to hypoxia. It also improves cerebral blood flow, thus having some impact on cognition.
The studies of the impact of S100 protein and its antibodies on the nervous system began in the 1960’s. During these researches, it was found that the low dosages of S100 antibodies can be used for the treatment of certain dependencies. And in 2001 the new drug was released – ProProTen 100.
Proproten marketed as a remedy for hangover relief, and the treatment for alcohol dependence. One of the claimed effects is reducing the urge to drink alcohol.
The active ingredient of Proproten-100 is the same as Tenaten – S100 antibodies. They are, in fact, the same drugs. The only difference is the product form and concentrations.
Tenaten available only in pill form for sublingual administration, in two variations – Tenoten for kids, with 10x smaller concentration of active ingredient, and standard adult version. The concentration is 10^-15 ng/g.
Proproten-100 is available in drops and pills form. The reason why alcoholism version of this drug available in the liquid form, is that you can treat an alcohol-addicted person without his permission, adding a few drops in his food or drinks. The concentration in Proproten is 10^-1991 ng/g.
The further researches of the substance revealed anxiolytic and antidepressant properties of S100 antibodies. And then a new drug comes to the market – Tenoten. Same active ingredient, but different indications for use and concentration. This time is was marketed as mild and safe anxiolytic with antidepressant and nootropic action.
Recommended dosage is 1-2 pills sublingually 2-4 times a day. The length of the course is from one to three months. The treatment course can be repeated after 1-2 months.
For the Proproten, the dosage is one pill each 30 minutes for the two hours. Then, one pill hourly for the 10 hours. After that, one pill each three hours until no symptoms of alcohol abstinence left.
There are even more remedies with S100 antibodies from the same manufacturer!
The drug Brizantin marketed as quit smoking pills. It contains twice more S100 diluted antibodies by weight, and antibodies to Cannabinoid type 1 receptor. The drug Dietressa from this manufacturer also contains antibodies to cannabinoid receptors (but without S100 antibodies), marketed as weight loss supplement.
The drug Divaza contains antibodies to S100 protein like Tenoten, and Antibodies to Endothelial Nitric Oxide Synthase (eNOS). This one marketed as Nootropic supplement that increases cognitive functions and motivation. The claimed effects include sleep improvement, headaches relief, anxiolytic and antidepressive action. Another drug, Impaza, contains eNOS antibodies without S100 and sold as a prevention of erectile dysfunction.
Kolofort contains the antibodies to the following substances: S100, human tumor necrosis factor alpha, Histamine. This remedy marketed as a treatment of intestinal diseases.
The fact that they sell same substances in the different wrappings seems suspicious.
User ReviewsThere are plenty of reviews in the Russian segment of the internet. Hundreds of them. Those user feedbacks are mixed – a lot of people say that Tenoten did not work for them and it’s just placebo. The others claim that it is efficient and safe anti-anxiety supplement. There are much of both negative and positive feedbacks.
The benefits reported by users are:
- Relief of anxiety symptoms.
- Antidepressant effect.
- Improve sleep.
- Mood improvement.
- No side effects.
Those who left negative feedback usually don’t mention any side effects. They didn’t notice any effect at all. I analyzed about 50 reviews, and near one-third of them stated that the drug was the useless waste of money. Only a few people reported dizziness and emotional numbness as a SE, although the drug leaflet says there are no side effects besides individual allergic reactions. Here is how users rank Tenoten and its analogs:
The reviews for Proproten-100 are mixed too. As the drug to reduce the alcohol craving, results mostly unsatisfying. Wives use it as a treatment of their husband’s alcoholism. And in some cases, it works, and the urge to drink disappears, sometimes not. Disulfiram and Cyanamide-based remedies definitely work better at this point.
The other effect of ProProTen, the alcohol hangover relief, seems more pronounced. Almost every review author admits that it really helps after a drinking binge.
Studies and Clinical trials
The title of the study is “Potentiated antibodies to brain-specific proteins s100: Impact on the biogenic monoamines and lipid peroxidation in alcoholized rats.”
The goal of this study was to evaluate the effect of S100 protein antibodies on the brain.
Rats received 25% ethanol solution at the 1.5-2 g/kg dosage for 15 days. After the cessation of ethanol, a part of alcoholized rats received 0.1 ml of S100 antibodies at the C1000 concentration, twice daily for seven days.
After that, both groups of rats they were decapitated. The content of neurotransmitters and their precursors in hypothalamus, hippocampus, amygdala, frontal cortex region and blood was measured to find the changes.
In alcoholized rats that did not receive treatment, norepinephrine and epinephrine content in the hypothalamus was 45% and 29% lower, respectively, compared to intact rats. At the hippocampus, the dopamine, norepinephrine, and epinephrine levels were increased by 2.5-4 times. Those changes clearly indicate hyperdopaminergic state and agitation.
Those changes in rats who received S100 treatment were less pronounced. Their levels of catecholamines in blood plasma also revealed the anxiolytic activity of the drug. And one thing to mention is that one of the authors of the study is specialized on homeopathy and related to the manufacturer.
The title of the next study is: “The psychological component of quality of life in patients with circulatory encephalopathy of the I-II stages during treatment with Tenoten."
The study was performed on two groups of 30 Patients each, with a diagnosis of cerebral atherosclerosis. The main group received standard treatment combined with Tenoten, while the control group received only standard treatment. The standard treatment includes medications for cerebral blood flow improvement (Vinpocetine/Ginkgo Biloba extract) and antiplatelet drugs (Aspirin/Clopidogrel).
Their psychological well-being was estimated by the following tests:
- Psychological General Well-Being Index.
- Center for Epidemiologic Studies Depression Scale.
- Hamilton Depression Rating Scale.
- Montgomery-Asberg Depression Scale.
- Hospital Anxiety and Depression Scale.
- Hamilton Anxiety Rating Scale.
You can see the results of the treatment at those infographics. The group who took Tenoten with their standard treatment feels a bit better than the control group. The difference, however, is not big. Also, there was no treatment+placebo group, would be interesting to compare.
This drug, in my opinion, can’t be considered as a Nootropic. The anxiolytic effect also not highly pronounced. And I think that the manufacturer is untrustworthy. But this is only my humble assumption.
Since there are not that many anecdotal experiences available on the English part of the internet, here are the Russian user reviews of Tenoten, translated from Otzovik website (sorted by the newest). These are not cherry-picked, all reviews included, either positive or negative.
The calming effect is very pronounced for me. Without drowsiness, apathy or any other side effects, you just respond less to stressors. Of course, no need to self-medicate, but if your doctor suggested Tenoten for you – listen to his recommendations, it’s a good remedy.
A simple placebo can give you more effects than this drug. For that money, you better to buy vitamins, valerian root or Leonurus.
Very good medication, after the two weeks course I don’t really need to take it three times a day as before. The effects are mild, my sleep normalized, and I stopped worrying about little things. I’ve taken two pills three times a day for the two weeks, and then one pill twice daily.
I have a 3 years old son and he got prescribed with Tenoten for children. After a week he began to limp and said that his feets hurt a lot. I’ve started to take this pills too and experienced pronounced joint pain in hands and feet. After cessation, the pains disappeared. I do not recommend them strongly.
Couple years ago my sister started to take Tenoten during her first exams. She was very pleased with this drug and recommended it for me. So, I’ve been using it for two weeks already. After the first week, my anxiety and inner tension disappeared. I didn’t tried other similar drugs, so I can’t compare with anything, but Tenoten definitely works. I will continue to take it since I have a stressful job.
I took two pills as suggested by the instruction, and after two hours experienced intense pulsating headache. Three pills of citramon didn’t helped. I had wasted my working day and money.
Perhaps I have treatment resistant neurosis with a sleep disorder, but after a month of taking this drug, I didn’t notice anything. I’ve bought it only because it was on a discount. Taken this as suggested by the instruction. The effects according to the leaflet and the commercial are huge, but the expectations weren’t fulfilled. I suggest not to trust commercials and waste your money on a bunk product.
I have some uncommon complaints. Sometimes I see an outline of the object when this object shifts to the left. After MRI scan, the neurologist prescribed a course of Mexidol, Idebenone, and Tenoten for me.
Every medicine prescribed had its own action. For example, while taking mexidol I am noticed that my memory has improved. Tenoten had different action – I became calmer, even during PMS. With the mexidol and Tenoten together my concentration also improved, irrelevant thoughts and noises stopped distracting me. The minor problems that disturbed me before, became so insignificant after Tenoten so I stopped thinking about them. No stress and anxieties. overall, good medication. I think it would be especially beneficial for women with pronounced PMS.
I’ve taken Tenoten while studies in college, during my springtime depression. A lot of exams ahead combined with my poor well-being, so I decided to give it a shot when I saw a commercial. On the 3rd day of the course, I noticed improvement of mood, concentration, and memory. Passed exams without any problems. That’s a good remedy. Pills have a sweet taste and remind chalk. Didn’t noticed side effects nor addiction.
Tenoten is a good remedy for stress relief, I tried it after cardiologist suggested it to me. Didn’t notice the effects immediately, looks like this drug has cumulative action. Tenoten helped me to sleep better, I feel more calm, no nervousnesses, but you need to take it long-term, at least for couple weeks. The treatment is individual for every person, it helps for me but it’s not a panacea, don’t expect 100% effect, the price is also high.
In 2013 doctor prescribed homeopathic Tenoten for me, from my neurasthenia. I took it for quite a long time and didn’t noticed any benefits. I think it’s a bunk product.
My therapist has prescribed “Tenoten” for me to treat my stress. I started to take it with my son, he took kid’s version of Tenoten. Three times a day sublingually, as suggested by the instruction. After a month, my kid became more focused, the effects was most pronounced for him. As for me, I began to sleep better with less anxiety and that’s all. Can’t say that the effects were caused by the pills, probably that’s just a simple self-control. That’s what I want to say – don’t rely on pills, you better to learn on how to control your emotions and combat anxiety. I think
I think I can recommend this, but it’s better to consult with a specialist before.
Taken during my exams, and I was less anxious than usually. I can’t eat and feel nauseous during stress, e.g before exams or any similar event. But when I have taken Tenoten everything was normal, I was able to eat normally. You should dissolve those pills. They have a sweet taste, they’re not disgusting or bitter. I can’t say that they work 100% and that all your worries and anxiety goes away completely, but you became less anxious. While I can’t fall asleep usually, with those pills I can. I suggest you try it, maybe it will help you too.
At the time when I was a student, I’ve taken Afobazol when I juggled exams and job. The effect was good, just what I needed. But this time doctor suggested Tenoten for me. As for me, Tenoten was very anxiolytic, didn’t noticed any effects. But I didn’t experience drowsiness as well as an adverse effect typical for anxiolytics. Summing this up, the drug was completely useless.