Semax is a peptide nootropic drug based on a fragment of adrenocorticotropic hormone, used in nasal spray form. It was developed in the Soviet Union in the 1980s.

Semax is used in the treatment of various neurological conditions such as stroke. Besides that, it can be used by healthy individuals to improve memory and attention and is widely used recreationally for its anxiolytic and antidepressant effects.

One of the main advantages of Semax is its safety. The drug is well-tolerated and does not cause serious side effects even if taken in excessive dosages.

Semax does have a fast onset of action and is able to cross the blood-brain barrier in four minutes after intranasal administration.

According to various researches and randomized controlled studies involving EEG, Semax does improve adaptation processes in the brain and increase its resistance to stressful conditions, hypoxia, and ischemia. The drug has pronounced antioxidant, antihypoxic, vasoprotective and neurotrophic action.

The drug also affects neurotransmitters balance in the brain. In studies, Semax increased levels of dopamine, serotonin, and its metabolite 5-Hydroxyindoleacetic acid significantly, after a single administration. The effect lasted for 24 hours after dosing.

Dosage & how to take Semax

Recommended dosage is 2-3 drops of nasal spray in each nostril four times a day. The length of the treatment course is 10-14 days. The course can be repeated if necessary.

Indications for use depend on the dosage form.

Indications for Semax 0.1% are:

  • Cognitive impairments caused by the cerebrovascular disorder, traumatic brain injuries and neurosurgery.
  • Encephalopathy, neurotic disorders, and recovery after stroke.
  • Improvement of adaptive capacity of the human organism in extreme conditions.
  • Prophylaxis of mental exhaustion during stressful monotonous work.
  • Optic nerve atrophy.
  • Cognitive disorders in kids above 7 years old, including attention deficit hyperactivity disorder.

The indication for use of 1% Semax solution is the acute ischemic stroke.

Contraindications for use are age below 7 years old, pregnancy and lactation, acute psychiatric disorders followed by anxiety, spasms, and hypersensitivity to the drug.

Possible side effect is irritation of the nasal mucosa and allergic reactions.