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Mexidol (aka emoxypine succinate)

Mexidol® (a trade name for emoxypine succinate) is a nootropic drug widely used in Russian neurology. It was developed in the Soviet Union in the beginning of 1980s. Mexidol has a wide spectrum of pharmacological action. One of its most important properties is...

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  1. Jane Doe

    Russian nootropics/medicines are hit and miss. They do not have rigorous double blind, large-scale clinical trials to back up the voluminous claims made about their indications, and the lack of side effects asserted about some of these drugs is disturbing because a) they’re either bullshit placebos or b) they’re deliberately not reporting side effects on product literature. If something has an effect, it will have side effects too. Most Russians will spend thousands more on Western drugs for serious ailments like cancer or schizophrenia than trust Soviet era pseudo-science (and it really is nonsense), so that tells you something. No effective neuroleptic has been developed in Russia. Russia is desperately pushing homemade drugs on its citizens because it can’t afford to run a healthcare system with the drugs currently used throughout the west and spend on its military at the same time. We’re talking about a country that sells phenobarbital drops over the counter, freely. So, it’s a case of self-experimentation and knowledge that nothing domestically developed in Russia meets standards of medicine used by Western countries – standards that are agreed as being GOLD standard in scientific circles around the world.

    • Admin

      Hi Jane,

      Thank you for your feedback and for the opportunity to explain our point of view 🙂

      A chemical compound is neither good nor bad. It is how people use it that determines the final effect.

      Here, we strive to provide quality new information regarding these drugs, as it may help people make more informed decisions. We do not assert that they are cure-all pharmaceuticals or anything like this but we merely informing people regarding their on-label usage and regarding the feedback that people had with these products. This is important because right now people are using these products of-label, while on-label usage can decrease the frequency of side effects and maximise their therapeutic potential.

      Yes, indeed the standards in Russia are different from those in the Western countries. Here, you do not need to spend around 2-3 billion of US dollars to get the drug approved by the respective government agency. It also does not take around 2-3 years to do that. The products here have been prescribed in most cases for decades by healthcare specialists. Books have been written about them. The fact that there are no double-side placebo controlled tests in English on your websites does not mean that these products are useless or that they come up with a bunch of side effects. It is simply wrong logic.
      If you don’t know something, it doesn’t mean that it doesn’t exist… It exists and always existed but you unfortunately have not known about it.

      To be honest, there is often a trade-off between side effects and effectiveness when it comes to pharmaceuticals. In statistics there is a so-called type 2 error, which is interpreted in different cases differently…

      In the US the current legal framework fosters large pharmaceutical companies to focus on the effects and they should be applicable for all people. Hence, you have benzos, opioids and amphetamines. These drugs are indeed very effective and can indeed be used for a variety of conditions. But in the same time they come with certain side effects.

      In Russia and the FSU, the approach has been different. The state focused on developing the drugs for general population, so most money was spent on clinical trials and not on meeting bureaucratic procedures or marketing. After you run a few dozen of clinical test on various kinds of population is is pretty obvious what the effect is, what method of administration should be used, etc. You don’t need 2-3 billion dollars for this… It can be much easier.

      Based on your assertions regarding “bullshit placebos?, it seems like you have no clue about the history of development of such drugs as Semax, or Phenotropil or many other. You do not know how, by whom, and why they were created e.g. how many years it took, what kind of clinical testing there were carried out, etc. You don’t know, that Semax won more than a dozen of different awards on European pharmaceutical contests and so on.

      And this is the case because a) You don’t have access to the information. b) Even if you had you cannot read Russian.
      You can make claims if you studied all the information available but you have not had this opportunity.

      You will not find many drugs available in the US, instead you will find those that are less efficient but that also have fewer side effects. For instance, instead of Adderall or Ritalin for ADHD, there will be Cortexin, Pantogam and some other drugs. Are they more effective? Of course no but they do come with significantly fewer side effects.

      And I want to stress one more thing. It is not Russian companies that are trying to get to the US with their products. It has never been the case. There is no opportunity to get to the US market as it is designed in such a way as to prevent smaller players to get there. It is the US companies that are trying to get to Russian market which is much easier to get to. They do the same unethical marketing to doctors practices that are widespread in the US to Russian doctors, so it is definitely not you who should complain…

      I would also add that most Russian pharmacists are bewildered at the fact that in the US Russian prescription medicine can be bought as bulk powder synthesized in China without any government control whatsoever. I think this situation is unhealthy and this is why there is this website.

      This topic is very long and I will stop at this point. But if anyone is interested, please contact us. As I said before, it is sad that there is no information regarding on-label usage if these drugs as it could be useful to many people.


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