Noopept (Also known as GVS-111) is a relatively new Russian nootropic substance, developed in 1992 by Zakusov Institute of Pharmacology. Noopept is a dipeptide drug, which is a combination of non-peptide Piracetam and a fragment of Vasopressin peptide. Pharmacological study of the drug showed its advantages over peptide and non-peptide analogs.
The developments were done within the idea that some regulatory neuropeptides may have a significant impact on memory and learning process. Unlike Vasopressin, which shows nootropic activity only when delivered to the brain structures, Noopept active even upon oral administration. It affects memory and learning process, and effective in the treatment of a wide variety of cognitive disorders.
Pharmacokinetic studies of this Nootropic showed good bioavailability to the brain.
Studies show that a 20-30mg daily dose of Noopept provides mild stimulating and anxiolytic effect, and also improves attention, memory and cognitive functions. By its anxiolytic action, it can reduce anxiety, irritability, insomnia and affective lability (mood swings). Noopept has a broad spectrum of nootropic action. It improves not only initial memory acquisition and consolidation but also the process of memory recalling, unlike Piracetam.
Neuroprotective effects of the drug manifested in increasing the resistance of brain tissue to damaging conditions like hypoxia (oxygen deficiency), intoxication, stressful events or traumatic injuries. Studies have shown that Noopept prevents neurodegeneration (the death of neurons) caused by the influence of toxic concentrations of glutamate and active forms of oxygen.
Noopept also can be considered as BDNF (Brain-derived neurotrophic factor) and NGF (nerve growth factor) supplement. Studies done in rats show that prolonged usage of Noopept does increase BDNF and NGF levels in the hippocampus. Those neurotrophic factors promote growth and survival of neurons and modulate the long-term memory.
Summing this up, you can expect the following effects of taking Noopept:
- Improvement of memory, attention, and cognitive functions.
- Anti-anxiety effect.
- Increased brain resistance to stressful conditions.
- Mild stimulating effect.
Mechanism of action
Noopept has a complex mechanism of action. The principle of memory-enhancing effect based not on simple cerebral blood flow improvement. Noopept has a direct impact on the synaptic structure, especially at the Hippocampus. The nootropic effect of the drug associated with one of its active metabolites, cyclo-Glycyl-L-Proline. Cycloprolylglycine is an endogenous peptide with anti-amnesic and selective anxiolytic effect. Recent studies show that Cycloprolylglycine can increase BDNF levels and acts as a positive allosteric AMPA modulator, thus having a significant impact on memory and learning.
In Russian clinical practice, Noopept used as the treatment of various neurodegenerative diseases. The reason for this its wide spectrum of Neuroprotective action.
Here are ways how Noopept protects your brain:
- Activation of endogenous antioxidant systems.
- Blockage of voltage-dependent calcium and potassium channels.
- Anti-inflammatory activity.
- Reduction of glutamate release.
- Increasing the level of antibodies to beta-amyloid and decreasing its toxicity. Beta-amyloid is a peptide that is involved in the development of Alzheimer’s disease. It is toxic to the nerve cells.
Noopept Dosage and How to take it
The therapeutic dosage of Noopept is 1000 times lower compared to Piracetam.
Suggested daily dosage is 20mg daily in two divided doses. The first dose in the morning, the second in the afternoon. You can increase the dosage for up to 40mg daily. It is not recommended to take Noopept later than 6 PM.
The length of Noopept cycle is 1.5-3 months. You can start taking it again after the one-month rest period. The effect becomes more pronounced during long-term usage.
The drug has high oral bioavailability, especially compared to Piracetam. However, you can take Noopept sublingually for a faster and more intense effect.
Another way to take Noopept is a nasal drops or spray. This method is for experienced users. You can dissolve a small amount of Noopept powder in saline, and use it as nasal drops. Start with a 0.1mg dosage. Saline is a 0.9% sodium chloride solution. You can buy a bottle for just two dollars. This method is not only effective but also very economical because of the lower effective dosage.
Side effects and contradictions
Noopept side effects are similar to Racetams. The most frequent side effect is a headache, which usually is a result of poor Choline intake. This side effect can be overcome with Choline supplementation. You can either take choline supplement like Alpha-GPC, CDP-choline, and Choline Bitartrate or eat a choline-rich diet. Eggs, liver, fish, and nuts are high in choline.
Less frequent and noticeable side effect is an increased blood pressure. If you suffer from hypertension, you should use Noopept cautiously.
Next possible side effect is irritability. If you experienced this side effect and it’s overcome the benefits, you can reduce the dosage or stop taking this supplement.
The least possible side effects are anxiety and dizziness. Some people who take Noopept before bed experience insomnia. This is why it should be taken not later than 6 PM.
The official contradictions are pretty standard. They include pregnancy, lactation, age below 18, Hypersensitivity to the drug, liver and kidneys dysfunction.
So, the possible side effects (from more to less frequent) is:
- Increased blood pressure.
- Allergic reaction.
Most people, however, don’t experience any side effects. But you should know about possible difficulties when taking this Nootropic. The responsible usage is the key to the satisfying results.
The Ability of Noopept to be metabolized to endogenous substances (substances that produce naturally in the body) is the main reason of its low toxicity and high therapeutic index.
The therapeutic index is the ratio between the lethal dosage and effective dosage. A safer drug has a higher therapeutic index. TI for Piracetam is 60, while TI for Noopept is 10.000. Such low toxicity determines the possibility of long-term usage with less risk of side effects.
Where can you get it
In the homeland of Noopept, Russia, this Nootropic is sold in pharmacies without a prescription. Just like in the other post-Soviet countries.
In the United States, you can buy Noopept as a dietary supplement from many different Vendors e.g this one. It can be a pure powder or some pre-mixed Nootropic stack with Noopept inside. Most of the US suppliers will gladly ship it overseas to any other country. If you place an order from outside the United States, don't forget to check your local laws!
Noopept review conclusion
Noopept is a very effective Nootropic for memory. It can increase your concentration and improve your cognitive functions as well. Besides that, some people may experience the stimulating and anxiolytic effect.
This Nootropic has higher bioavailability compared to Piracetam, and significantly less effective dosage. Low toxicity and abuse potential allow long-term usage of Noopept.
Some people experience side-effects. For someone, the benefits of Noopept overweight it, for some people not. So the best way to test how your body responds to this substance is to start with the small dosages. Just like with any Nootropic or any other supplement.
The benefits of Noopept
- Strong Nootropic effect. Significantly improves memory processing and recall, concentration and cognitive functions.
- A wide range of Neuroprotective action.
- Small therapeutic dosage, particularly in the intranasal administration.
- Low toxicity (20 times higher therapeutic index than Piracetam).
- May used long-term.
- It may be difficult to dose such little amount of powder precisely. Having a pocket scales or taking capsulated version makes everything easier.
- Extremely bitter taste. It’s even more noticeable during sublingual usage of Noopept. And again, capsules are a solution.
- Side effects. They are rare but possible.
- Ostrovskaia R.U. et al The original novel nootropic and neuroprotective agent noopept (2002)
- Gudasheva TA, et al The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine . Eur J Drug Metab Pharmacokinet. (1997)
- Ostrovskaya RU, et al Noopept stimulates the expression of NGF and BDNF in rat hippocampus . Bull Exp Biol Med. (2008)
- Bochkarev VK, Teleshova ES, Siuniakov SA, Davydova DV, Neznamov GG. Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin. Zh Nevrol Psikhiatr Im S S Korsakova. 2008
- Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009
- Amelin AV, Iliukhina AIu, Shmonin AA. Noopept in the treatment of mild cognitive impairment in patients with stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 2011
- Bobkova NV, Gruden' MA, Samokhin AN, Medvinskaia NI, Morozova-Roch L, Uudasheva TA, Ostrovskaia RU, Seredinin SB. Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice. Eksp Klin Farmakol. 2005
Here are the Noopept reviews from the Russian on-label users. Translated from the otzovik website, sorted by the newest. All reviews included, either negative or positive. Since this is only anecdotal experienced this information should be taken with a grain of salt, for more objective information use references listed in the overview tab.
I’m getting old and my brain is like getting rusty. After searching the internet I found that the drug Noopept is just what I need, that it will help me to think faster. Bought it, took it for a month, and indeed I started to notice positive improvements.
My drowsiness has gone, brain now works better with the new information, my reaction improved. I even signed for additional educational courses, and surprisingly, I perform same as the people twice younger than me. Memorizing gets easier, but most important that memorized information stay in your memory rather than gets forgotten on the next day.
The neurologist prescribed me two months course of those pills to fix my low well-being caused by poor blood circulation in the brain.
The first impression was good. The first two weeks I felt more energy, everything was easier. Now I think that it was caused by high expectations and placebo effect. After a month I stopped taking it.
I continued the course later and decided to take it for two months as the doctor prescribed. Just from the first days, it solved one of my problems – waking up in the morning. I didn’t have such problems before, even if I slept for 3-5 hours. But maybe because of the stress or because of my age, I’ve needed about 30-40 minutes to wake up. The alarm clock rings every 5 minutes but I can’t even open my eyes. And even after I woke up, I still feel drowsy for about hour. It’s not normal for me, the presence of problems is obvious.
So, after Noopept I started to wake up without problems almost immediately. Regarding the drowsiness and absent-mindedness, I also noticed an improvement. After the three weeks, I realized that this is not a placebo effect, but the actual effects from the drug. And because of this, I admit that it’s working.
Noopept has cumulative action. And after a week I started to notice that I wake up before the alarm. To be exact, my brain is waking up, through my sleep I feel that it’s the morning already and soon I’ll need to wake up. But my body is still inert, I can’t pull myself up, move, or stand up. The next is worse – day to day my brain started to wake up earlier and earlier. My alarm clock is set to 6 AM, I started to wake up at 5 AM, then 4:30 AM, after that at 3:30 AM. And it could be ok if I could really wake up. But at this time my head was full of thought, sometimes I was falling into sleep again and saw weird unpleasant dreams. But I wasn’t able to wake up, can’t even move. So it was just a wasted time. And afternoon I experienced intense drowsiness and sleepines. Fell asleep at my work.
So, how should I interpret this? Pills gave me so much energy, so my need for sleep decreased drastically? Then I would be able to wake up and do something. But laying in the bed while you understand everything but can’t get up is really unpleasant. I tried to fix this, started to take pills at the first half of the day. But it didn’t help.
Besides that, when taking Noopept I experienced increased heart rate in the first half of the day. Of course, I didn’t experience any memory and attention increase on the background of those side effects, everything was exact the opposite. I was exhausted and irritated. So far I took it for seven weeks and then stopped. After cessation side effects disappeared. I guess I am hypersensitive to this drug.
After retirement, I didn’t leave my job because I still feel the desire to work. But the age makes itself felt, my brain started to work worse and my memory has weakened. Everything started with my memory, I started to forgot little things, like a shopping list or I might forget my wallet or ID. But my memory was very good before.
Then I noticed that I have problems understanding what I just read/heard. Clearly the signs of the old age. I went to a doctor and he prescribed Noopept for me, I bought it and started a seven weeks course. After finishing the course here is my impression.
The main thing is that my memory has returned. It became almost the same as before, my forgetfulness stopped. While reading the books I noticed that I don’t need to read one sentence many times. And while watching films, no need to rewind it anymore to understand the plot. At my work, sometimes I even perform better than my younger colleagues.
Recently I noticed absent-mindedness that I didn’t experience before. I regularly forgot keys, phone calls or I could forget at grocery what I need to buy. Despite the fact that I was able to memorize everything before without any shopping lists. Summing this up, I experienced some problems with memory. They weren’t significant, but I worried about it and decided to help my brain. After consulting with my nurse friend I bought Noopept and started to take two pills daily.
The 1.5 months course passed. At first, I thought that the drug does not work since I didn’t notice anything. But after some time I’ve changed my mind. Here are the effects I noticed after taking it:
- More energy in the morning.
- I’m no longer forgetful.
Didn’t experience any side effects like headaches or allergic reactions, the drug suits me well. I’m thinking about another course in 6-12 months.
I take this medication for three weeks, one pill in the morning. And now I have problems falling asleep for the past couple days. It takes an hour or more. Now after reading all the reviews I understood, that this reacting might be caused by the drug, usual reaction. Now I’m stopping taking it. Regarding memory – it became better.
Noticed some problems with memory, and my doctor prescribed Noopept for me. Almost finished the pack, only 11 pills left. Theoretically, I already should notice improvements in memory. But sadly, I don’t see any improvements. And I started to sleep poorly (but I don’t know is this caused by this drug or not). According to reviews, it’s a good drug, but I guess it just doesn’t suit me. And because of that, I won’t recommend it.