Donormyl (a trade name of doxylamine succinate) is a sleep aid of ethanolamine class. It is antihistamine drug that works by inhibiting H1-histamine receptors. Besides that, it does have pronounced sedative and anticholinergic action.
According to studies, Donormyl can be used as an alternative to benzodiazepines in the treatment of insomnia. Doxylamine reduces time to fall asleep and increases the duration & quality of sleep significantly without interfering with sleep architecture.
The sleep-inducing effect of this drug at the 25 and 50mg dosages is more pronounced compared to that of secobarbital at the 100mg dosage, and almost equivalent to the 200mg dosage.
The indication for use is insomnia and sleep disturbances. The drug also sometimes used in combination with pyridoxine, in the treatment of nausea and vomiting of pregnancy.
Recommended dosage is 15mg, 15 minutes prior to bedtime. The dosage can be raised to 30mg if necessary. The length of the treatment course is 2-5 days.
Contraindications for use are:
- Hypersensitivity to the drug.
- Closed-angle glaucoma.
- Prostatic hyperplasia and urinary retention.
- Age below 15 years old.
Possible side effects include daytime sleepiness, dry mouth, accommodative paresis, constipation and urinary retention.
Donormyl can potentiate the effects of barbiturates, benzodiazepines, clonidine, opioids and antipsychotics. Coadministration with other anticholinergic drugs may increase the frequency of side effects. It is not recommended to take Donormyl with alcohol, as it can increase the sedative effect.